Kulakov, Moscow, Russia. Gonadal differentiation has a determinative influence on sex development in human embryos. Disorders of sexual development DSD have been associated with persistent embryonal differentiation stages. Clinical investigations included karyotyping, ultrasound imaging, hormonal measurement and investigations of gonadal morphology. The male characteristics in the embryo are imposed by testicular hormones.
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Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq
Genetics of Sexual Differentiation | GLOWM
Sexual determination in mammals is genetically and hormonally controlled. Human gonads serve several functions. Gonads are the repository of germ cells and influence the maturation of these cells into oocytes and spermatocytes. Gonads produce the hormones that control the development of the internal and external genitalia and that regulate pubertal development and the reproductive cycle, including sperm maturation in the male, and ovulation and menstruation in the female. These functions are mediated by the specialized cells of the gonad that include germ cells, support cells, and hormone-producing cells. The germ cells of the differentiated gonads reside in compartments that place them in functional contact with support cells.
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Metrics details. Despite some advances in recent years, the genetic control of gonadal sex differentiation during embryogenesis is still not completely understood. To identify new candidate genes involved in ovary and testis development, RNA-seq was used to define the transcriptome of embryonic chicken gonads at the onset of sexual differentiation day 6. RNA-seq revealed more than genes that were transcribed in a sex-biased manner at this early stage of gonadal differentiation. Comparison with undifferentiated gonads revealed that sex biased expression was derived primarily from autosomal rather than sex-linked genes.
Definition noun Sex as determined based on the gonadal tissue. Supplement In humans, the presence of testicular tissue generally indicates male sex while the presence of ovarian tissue generally indicates female sex. See also: gonad , testis , ovary. Illusions are the perceptions and sensory data obtained from situations in which human error prevents us from seeing the.. This tutorial elucidates body temperature regulation.
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