Is sickle cell anemia sex linked

We inherit genes from our biological parents in specific ways. One of the ways is called autosomal recessive inheritance. Autosomes don't affect an offspring's gender. Most people don't know they carry a recessive gene for a disease until they have a child with the disease, or they have another family member with the disease.
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02.12.2019
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How Is Sickle Cell Anemia Inherited?

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Sex-linked, limited, and influenced

Five factors have been shown to influence the fold variation of fetal hemoglobin Hb F levels in sickle cell anemia SS : age, sex, the alpha-globin gene number, beta-globin haplotypes, and an X-linked locus that regulates the production of Hb F-containing erythrocytes F cells , ie, the F-cell production FCP locus. To determine the relative importance of these factors, we studied Jamaican SS subjects from a Cohort group identified by newborn screening and from a Sib Pair study. The association between the beta-globin haplotypes and Hb F levels becomes apparent if the influence of the FCP locus is removed by analyzing only individuals with the same FCP phenotype. The variation within each FCP phenotype is modulated by factors associated with the three common beta-globin haplotypes and other as yet unidentified factor s.
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Sickle-Cell Anemia: A Look at Global Haplotype Distribution

Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S Hb S which, when homozygous Hb SS is the cause of sickle cell anemia. Changes of puberty, correlated with a delayed growth spurt, begin late in both male and female sickle cell anemia individuals with repercussions on sexuality and reproduction. The objectives of this exploratory and descriptive study were to characterize the development of sexuality in adults with sickle cell anemia by investigating the patient's perception of their sex life, as well as the information they had and needed on this subject. Twenty male and female sickle cell anemia patients treated at the Hemocentro Regional de Uberaba UFTM with ages between 19 and 47 years old were enrolled.
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Sickle cell anemia is a genetic disorder where the protein hemoglobin is mutated. Hemoglobin clumps together inside red blood cells and causes their shape to change into a crescent. This impairs the function of red blood cells and their ability to carry oxygen around the body. Become a Study.
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